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Sağlık Kanser Tedavisinde Yeni Gelişme 11 Eylül 2018 15:57
California Üniversitesinden bilim insanları, bir hastadan çıkarılan, en agresif beyin kanseri türü glioblastoma hücrelerini, laboratuvar ortamında ve nakledilen fareler üzerinde inceledi.
Araştırmada, GABP proteininin "GABPbeta1L" adındaki küçük bir bölümünün, kanser hücrelerinin süresiz bölünmesi nin etkinleşmesinde kilit rol oynadığı tespit edildi.
Sonsuz bölünmeyi durdurdu Gen düzenleme aracı CRISPR kullanarak GABP proteininden beta1L unsurunu çıkaran bilim insanları, yöntemin işe yaradığını ve beta1L yoksunluğunun, kanser hücrelerinin sonsuz bölünme eylemini durdurdu ğunu belirledi.
"Yeni ilaç geliştirilmesinde umut verici" Araştırma ekibinin lideri nöro-cerrahi ve nöro-onkoloji Profesörü Joseph Costello, bulguyu, glioblastoma ve TERT geni mutasyonlarına sahip diğer birçok kanser türünde beta1L'yi hedef alan yeni bir ilacın geliştirilmesi açısından ümit verici olarak nitelendirdiğini söyledi.